Balance your gut, balance your life.
1.5 LAKH + HAPPY CUSTOMERS
BACKED BY GUT MICROBIOME EXPERTISE
Dr. Sumit Siddharth, PhD
Scientific Advisor · Gut Microbiome
- 🔬 Research Associate · Johns Hopkins University, USA
- 📄 50+ peer-reviewed publications in gut microbiome research
Inc. of all taxes.
Delivery & Shipping Details
WHO-GMPISO 22000ISO 13485
FSSAI 11525998000078Fermedicius Labs, Bengaluru
Clinically validated in human trials | Cultures sourced from USA & Germany
Acid resistant. Gut-Brain Focused. Beyond standard probiotics.
Cheap probiotics dissolve in stomach acid. MindFlora uses patented DRcaps® acid‑proof delivery with 12 clinically studied psychobiotic strains to support the gut–brain axis.
The gut–brain axis
- 01Vagus nerve 80% of all signal traffic from gut to brain.
- 02HPA axis Stress and cortisol response between gut and brain.
- 03Immune signalling Cytokine signalling and neuroinflammation.
- 04Neurotransmitters Gut regulates 90% of serotonin, plus GABA and BDNF.
01Each capsule contains
- 12 psychobiotic strains
- 35 B CFU
- Prebiotic inulin
- 50 mg
- Vitamin D3 (cholecalciferol)
- 600 IU · 100% RDA
- DRcaps® delayed-release shell
- patented
02The evidence
01Strain-by-strain evidenceMechanism, findings and source for all 12 strains12 strains
L. acidophilusCognitive supportHuman RCT3.5B
Mechanism. Produces SCFAs, restores microglial peroxisomal function, suppresses NF-κB, stimulates NGF and BDNF.
- Improved verbal memory in an elderly RCT (Hopkins Verbal Learning Test-Revised)
- Drove cognitive recovery via the microglial peroxisomal pathway
- Lowers luminal pH, inhibiting Clostridium, Salmonella and E. coli
In this formula. Studied as a triad with B. longum and B. bifidum in Alzheimer's cognition RCTs.
Cell Host & Microbe, 2025View source
L. rhamnosusHPA axis regulationSystematic review3.5B
Mechanism. Raises GABA-A receptor expression, prevents cortisol hyperactivation, upregulates BDNF/TrkB via 5-HT1A.
- PRISMA review of 15 studies: consistent reduction in stress-induced anxiety
- Strain HN001 improved DASS-21 depression and anxiety scores
- Postpartum depression reduced in a double-blind RCT
In this formula. Pairs with B. longum — GABA modulation plus limbic activity, a dual anxiolytic route.
Nutrients, 2024 · PMC12766537View source
L. caseiMood and cytokine balanceHuman RCT3.0B
Mechanism. Stimulates NK-cell cytotoxicity, raises IL-10, suppresses TNF-α and IL-6, reinforces the epithelial barrier.
- Improved mood in an elderly cohort, strongest where baseline mood was lowest
- Reduces the pro-inflammatory cytokines linked to low mood and brain fog
- Among the best gastric-acid survivors of the Lactobacilli
In this formula. Complements L. rhamnosus through independent cytokine pathways.
PMC8840472, 2022View source
L. helveticusCortisol controlfMRI RCT3.0B
Mechanism. Reduces urinary free cortisol, dampens the HPA stress response, limits prefrontal neuroinflammation.
- fMRI RCT: significantly altered activity in emotional-regulation regions
- Significant reduction in 24-hour urinary free cortisol — a direct HPA biomarker
- Reduced activation in lateral orbital and ventral cingulate gyri under a stress task
In this formula. With B. longum, the most studied psychobiotic pairing in human brain imaging.
NCT03615651 · Frontiers in Nutrition, 2022View source
L. plantarumNeuroprotectionSystematic review3.0B
Mechanism. Raises BDNF and serotonin in the prefrontal cortex, lowers TNF-α and IL-6 in brain tissue.
- Named most promising species for neurodegeneration symptoms in a 2024 review
- Broadest genome of any Lactobacillus — adapts across gut niches
- Additively reduced depression, anxiety and sleep disturbance with B. longum
In this formula. Third strain in the fMRI-validated R0052 / R0175 / R1012 combination.
PMC10931784, 2024View source
L. reuteriSerotonin synthesisHuman RCT2.5B
Mechanism. Stimulates enterochromaffin cells to release 5-HTP, promotes oxytocin via vagal signalling, produces reuterin.
- Top serotonin promoter in a five-strain neuronal cell screen
- RCT in 200 postpartum women: significant mood improvement
- Reduced IBS symptoms across multiple paediatric RCTs
In this formula. Metabolically symbiotic with B. breve, which supplies 1,2-propanediol.
Nutrients, 2023 · PMC10458832View source
B. bifidumGut barrier integrityHuman RCT3.5B
Mechanism. Reinforces ZO-1, occludin and claudin, upregulates secretory IgA, produces acetic and lactic acid.
- 12-week RCT: improved cognitive function in Alzheimer's patients
- Reduces intestinal permeability and the endotoxaemia behind neuroinflammation
- Promotes regulatory T-cell differentiation and IL-10
In this formula. Part of the clinically studied acidophilus / longum / bifidum triad.
Food Bioengineering, 2024View source
B. breveEpigenetic modulationHuman RCT3.0B
Mechanism. Inhibits LSD1, the demethylase controlling neurotransmitter gene expression; promotes GABA and serotonin.
- Top-ranking GABA and serotonin promoter in neuronal cell screening
- Improved mood and self-confidence in 200 new mothers, with L. reuteri
- Gene-expression changes can persist beyond the supplementation period
In this formula. Feeds 1,2-propanediol to L. reuteri, amplifying its serotonin output.
PMID 34515196, 2021View source
B. longumAnchor psychobioticfMRI RCT3.5B
Mechanism. Modulates limbic and emotional processing regions, reduces urinary cortisol, produces GABA precursors.
- fMRI RCT: significantly altered limbic, emotional and cognitive processing
- Reduced stress-cortex activation during the Montreal Imaging Stress Task
- Additively reduced depression, anxiety and insomnia with L. plantarum
In this formula. The anchor — pairs with helveticus, plantarum, acidophilus and bifidum.
NCT03615651 · Frontiers in Nutrition, 2022View source
B. lactisImmune and antioxidantPreclinical3.0B
Mechanism. Enhances NK-cell cytotoxicity, stimulates IgA and IgG, lowers CRP and IL-6, upregulates superoxide dismutase.
- Up to 70% ROS reduction alongside L. reuteri in a validated ageing model
- Meta-analyses confirm NK-cell and IgA stimulation in older adults
- Improves antibody response to influenza vaccination in elderly cohorts
In this formula. Combined with L. reuteri for oxidative-stress reduction.
PMC12652852, 2025View source
S. thermophilusMicrobiome groundworkHuman RCT2.0B
Mechanism. Rapidly produces L(+) lactic acid to acidify the gut, synthesises folate, produces lactase.
- Creates the acidic conditions Bifidobacteria need to colonise
- Produces folate (B9), a required co-factor for serotonin and dopamine synthesis
- Part of a multi-strain formula that altered emotion-regulation brain activity on fMRI
In this formula. The infrastructure strain — raises colonisation success for the other eleven.
PMC9104811, 2022View source
B. coagulansSpore-form deliveryHuman RCT2.5B
Mechanism. Forms heat-stable endospores surviving pH 1.5–3.5, germinating in the small intestine; produces butyrate.
- 8-week RCT: significant reduction in anxiety and depression scores
- Systematic reviews confirm IBS-D symptom relief including bloating
- Stable at ambient temperature beyond 24 months, no refrigeration
In this formula. The delivery guarantee protecting the stated 35 billion CFU across all strains.
NCT06629441 · PMC12525987, 2025View source
Evidence grade across all 12 strains2 fMRI RCTs7 human RCTs2 systematic reviews1 preclinical
02Combinations studied togetherSix pairings tested together in published trials6 pairings
| Combination | Study | Result |
|---|---|---|
| L. helveticus R0052 + B. longum R0175 + L. plantarum R1012 | Human fMRI RCT, 22 subjects, crossover, 2022 NCT03615651 | Altered limbic and emotional brain activity; reduced stress-cortex activation |
| L. reuteri PBS072 + B. breve BB077 | Human RCT, 200 postpartum women, 2021–23 | Top serotonin and GABA promoters; reduced postpartum depression scores |
| L. acidophilus + B. longum + B. bifidum | 12-week human RCT, 2023–24 | Improved cognitive function in Alzheimer's patients |
| B. longum P77 + L. plantarum P72 | Controlled animal study, 2025 | Additive anti-depression, anti-anxiety and anti-insomnia via GABA/5-HT |
| L. reuteri PBS072 + B. lactis BL050 | Validated longevity model, 2025 | 70% ROS reduction; 20% locomotion improvement |
| L. acidophilus + L. rhamnosus JB-1 | Systematic review, 15 studies, 2024–25 | HPA axis modulation; cortisol reduction; GABAergic anxiety relief |
03₹500 probiotic vs MindFloraEight points of difference, side by side8 points
A · ₹500 probioticB · MindFlora
- Probiotic only01Synbiotic — probiotic + inulin + vitamin D3
- Targets digestion only02Targets the gut–brain axis: mood, stress, cognition, digestion
- Strains picked on CFU count and cost03Strains picked on published clinical evidence
- Dissolves in stomach acid at pH 1.5–3.504DRcaps® shell plus B. coagulans spores survive it
- 50–100B CFU across 1–2 strains0535B CFU across 12 targeted strains
- No prebiotic, no vitamin D06Inulin 50 mg + D3 600 IU, 100% RDA
- Genus and species only on the label07Full strain-level nomenclature disclosed
- Blends assembled for marketing08Mirrors combinations tested in human RCTs
Inulin — 50 mg
Fructan fibre fermented by the Bifidobacteria and Lactobacilli in the capsule into butyrate, the primary fuel for gut epithelial cells and an anti-inflammatory signal to brain microglia.
Vitamin D3 — 600 IU
Receptors in the hippocampus and prefrontal cortex regulate BDNF, NGF and neuroinflammatory cytokines. NFHS 2019–21 data puts deficiency above 70% in urban Indian adults.
04Full reference listEvery citation, linked to its source18 sources
- Hu et al. (2023). Verbal memory improvement in elderly subjects, RCT. pubmed 41889579
- Zhang et al. (2025). L. acidophilus and cognitive recovery via microglial peroxisomal function. Cell Host & Microbe. cell.com
- Frontera-Ximenis et al. (2024). Psychobiotics in psychiatric and cognitive disorders. PMC11085935
- Meta-analysis (2024). Probiotic supplements and cognitive function. PMC12645680
- Juvale & Arulsamy (2025). L. rhamnosus on stress-induced anxiety: PRISMA review. PMC12766537
- Yang et al. (2024). L. rhamnosus HN001 and mental wellbeing: RCT. 10.3390/nu16172936
- Chen et al. (2024). L. rhamnosus KY16 via the 5-HTP/BDNF/TrkB pathway. PMID 39311539
- Rode et al. (2022). Brain responses, emotional task: fMRI RCT. 10.3389/fnut.2022.827182
- Edebol Carlman et al. (2022). Brain responses during arithmetic stress task. PMC9002567
- Perna et al. (2021). L. reuteri + B. breve on the gut–brain axis. PMID 34515196
- Vicariotto et al. (2023). Postpartum mood and depression: RCT, n=200. PMC10458832
- Park et al. (2025). B. longum P77 + L. plantarum P72 via GABA/serotonin. PMC12523862
- Systematic review. L. plantarum in neurodegenerative disease. PMC10931784
- Palanza et al. (2025). Strain-specific geroprotection. PMC12652852
- Zhang et al. (2025). W. coagulans BC99: 8-week RCT. PMC12525987
- Frontiers in Pharmacology (2024). Probiotics as gut–brain axis modulators. 10.3389/fphar.2024.1348297
- Jeon et al. (2022). L. acidophilus EG004 on cognitive ability. PMC8754107
- Meher et al. (2024). Triad combination in Alzheimer's cognitive improvement. 10.1002/fbe2.12081
Manufactured by Fermedicius Labs Pvt Ltd, Bengaluru (WHO-GMP, ISO 9001, ISO 22000, ISO 13485). Every claim above is traceable to a peer-reviewed source listed in section 04. Evidence relates to the individual strains and combinations as published
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Delivery Details
Description
MindFlora Multi Strain Probiotics by The Gut Story is a powerful daily probiotic supplement designed to support your gut health, brain function, immunity, and overall wellbeing. Each capsule delivers 35 Billion CFU of carefully selected probiotic strains, combined with Prebiotic Inulin and Vitamin D, to strengthen your gut-brain connection and keep you feeling balanced, clear, and energized every day.
Key Benefits
- Cognitive Health - Supports mental clarity, memory, and focus
- Immunity Boost - Enhances immune function through gut health
- Relieves bloating, gas & constipation
- Strengthens gut-brain connection for better focus & calm
- Promotes restful sleep & stress reduction
Composition
Each Capsule Contains
Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus helveticus, Lactobacillus plantarum, Lactobacillus reuteri, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium lactis, Streptococcus thermophilus, Bacillus coagulans
🎁
Extra ₹100 OFF on Prepaid Orders
ADVANCED MULTI-STRAIN PROBIOTIC BLEND
Formulated with 35 Billion CFU to restore balance, ease bloating, and support gut health.
COGNITIVE HEALTH SUPPORT
Backed by gut–brain research to improve focus, clarity, and overall mental well-being.
PREBIOTICS FOR LASTING WELLNESS
Feeds good bacteria with plant-based prebiotics for stronger, long-term microbiome health.
IMMUNE & GUT-BARRIER DEFENSE
Supports intestinal integrity and strengthens your natural immune system.
DIGESTIVE COMFORT & REGULARITY
Promotes smoother digestion, reduces discomfort, and helps maintain daily regularity.
VEGAN, NON-GMO & CLEAN FORMULA
Made with plant-based ingredients, free from added sugar, gluten, and artificial fillers.
MindFlora™4-Month Transformation Timeline
Weeks 1–4 | Gut Reset & Comfort
Beneficial probiotic strains begin colonizing the gut while Vitamin D and key lactobacilli support gut lining repair. Bloating reduces, digestion smoothens, and post-meal comfort improves.
Weeks 5–8 | Gut–Brain Activation
Psychobiotic strains activate the gut–brain axis, supporting serotonin and GABA signaling. Sleep quality improves, stress response calms, and mood balance becomes noticeable.
Weeks 9–12 | Stress Resilience & Clarity
The stress (HPA) axis stabilizes, helping normalize cortisol rhythms. Focus sharpens, emotional resilience strengthens, and mental fatigue reduces.
Weeks 13–16 | Lasting Balance & Vitality
A resilient, self-sustaining microbiome supports long-term calm, steady energy, and mental clarity. MindFlora™ becomes part of your body’s natural balance.
How Mindflora differs from the other probiotics
Understanding the difference
MindFlora
Typical Probiotics
Focus
Targets neurotransmitters, stress, and mood
Focus
Focus on digestion only
Formulation
Clinically studied psychobiotics
Formulation
Generic strains
How it actually works
Serotonin, GABA, BDNF & cortisol pathways mapped
How it actually works
No clear mechanism link
How MindFlora Fits Into Your Daily Routine
01
Begin Your Day Focused
"Rise energized and clear-headed — MindFlora optimizes serotonin and cortisol balance, so you stay sharp and calm through even the most hectic mornings."
02
Handle Stress with Ease
"MindFlora modulates your stress response, keeping you composed and resilient — whether you're navigating deadlines, commutes, or unexpected challenges."
03
Rest Deeply, Rise Restored
"Through enhanced gut-brain signaling and melatonin support, MindFlora delivers rejuvenating, natural sleep — just pure rest, no next-day fog."
Before
After
